The major roles of the commission are:
- Advocate for HIV and AIDS issues in order to create a good enabling environment for an effective HIV response. Also promote human right based approaches and multi-sectoral involvement and participation.
- Capacity building of key implementers on how to design, execute and assess HIV interventions. Of recent, orient stakeholders on a new strategic shift that emphasize on targeting most at risk populations.
- Development of national guidelines on HIV and AIDS. This includes periodic strategic plan for HIV
- Coordination of the national response.
Resource mobilization and Monitoring and evaluation